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May
03

Study supports 2 mg IM vitamin K as prophylactic dose to prevent vitamin K deficiency bleeding

A vitamin K prophylactic regimen of 1 mg of vitamin K orally at birth followed by a daily oral dosage of either 25 or 150 µg fails to prevent vitamin K deficiency bleeding in breastfed infants with still unrecognized biliary atresia. In the study by the Netherlands Study group of Biliary Atresia Registry (NeSBAR) reported in May 2016 issue of the journal Pediatrics, vitamin K deficiency bleeding occurred in 82% infants of the 25 µg group, in 82% of the 150 µg group, but in only 4% of the IM 2 mg group. No intracranial hemorrhage was reported in the IM 2 mg group.